As a musician, she came to public attention playing guitarist Charlie in Totally Frank on Channel 4 which led to the band Frank releasing the Devil's Got Your Gold album. She was credited for music in the BBC Films/Film London/Spring Pictures 2012 film Strawberry Fields and is a member of the band Troubadour Rose.
As an actress, Afferson frequently appears in episodes of television series. Examples include The Shadow Line, House of Anubis, Silent Witness, Father Brown (2013 TV series), Casualty (TV series) and Playhouse Presents. On stage, she appeared in On the Waterfront (based on the 1954 film) at the Theatre Royal, Haymarket and Rough Music at the King's Head Theatre.